Inflammation and Cancer
What is inflammation? What is the relationship between inflammation and cancer?
Inflammation is commonly known as heat or fire in the body caused in response to tissue damage resulting from injury, infection, autoimmune response, exposure to toxins, and a range of other inflammatory offenders. Inflammation may produce swelling, irritation, redness, and pain. The damaged area attracts immune cells producing inflammatory chemicals that work to kill toxins and stimulate regrowth of cells and blood vessels to mend the wound. Many cases are acute with inflammatory chemical production ceasing when the tissue is restored.
Sometimes the inflammatory response does not stop. The alarm reaction in the body continues in the presence of ongoing injury from inflammatory offenders. The continued inflammatory panic of a wound-repairing attempt gone wrong creates a hostile environment. A chronic state of inflammation causes a chronic, confused immune response creating chaos instead of repair. The result is a terrain and overall environment in the body that supports cancer1-2.
Similar mechanisms appear to be associated with inflammation, immune response, and cancer such as decreased cell death (apoptosis), increased cell growth, and increased blood supply (angiogenesis). During acute inflammation, those processes allow injured tissue to repair. During chronic inflammation and cancer, those processes provide essential support to cancer cell growth.
Inflammation appears to both initiate and fuel cancer. The initiation is linked to a chronic state of inflammation and immune response. The fuel involves various ways cancer cells produce inflammation to sustain their growth. Ultimately, inflammation and cancer reciprocally feed one another.
A major mechanism through which inflammation fuels cancer involves the production and activity of a protein called nuclear factor kappa beta (NF-kB). Cancer promoting triggers of nuclear factor kappa beta include injury, other inflammatory offenders such as diet, acidity, carcinogens, bacteria, viruses, oxidation, stress, radiation, chemotherapy, environmental stimuli, and additional factors. Nuclear factor kappa beta is considered a master switch in cancer accounting for approximately 95% of all cancers. Research indicates that nuclear factor kappa beta decreases cancer cell death (apoptosis) and increases cancer cell growth, blood supply to tumors (angiogenesis), invasion, and metastasis (1-5). Nuclear factor kappa beta also fuels inflammation through COX-2 enzymes and cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8). Studies suggest that high levels of IL-6 are correlated with shorter survival in some people with cancer. Along with promoting cancer invasion, IL-6 stimulates vascular endothelial growth factor (VEGF) responsible for increased blood supply to tumors through angiogenesis2.
What is the relationship between inflammation and cancer survival? What are the potential benefits of low inflammation levels in the body?
Published research studies demonstrate inflammatory levels correlate with cancer.
Low inflammatory levels appear to indicate reduced cancer risk and improved cancer survival6.
High inflammatory levels appear to indicate increased cancer risk and poorer prognosis. Inflammation also decreases quality of life, impairs immune functions, plays a central role in cancer cachexia7, and lowers toleration of some anti-cancer therapies8.
Research indicates that measuring inflammation may predict survival time for many cancers9. Some studies suggest that people with the lowest levels of inflammation were twice as likely to live through the next several years10-12.
Low inflammation levels also support the prevention, control, and reversal of inflammatory conditions associated with other health problems.
What are inflammatory offenders?
What are some natural anti-inflammatory strategies?
Anti-inflammatory strategies include specific foods and supplements, exercise, balance in body, mind, and spirit, and the elimination of environmental toxins.
What are specific anti-inflammatory strategies with foods and supplements?
In Life Over Cancer, Keith Block, MD references the following anti-inflammatory foods and supplements. The optimal anti-inflammatory supplements for each individual may depend on the specific inflammatory molecules present at high levels.
To inhibit nuclear factor kappa beta central to fueling inflammation and cancer, Jeanne Wallace, PhD, CNC references some of the following natural agents3.
What tests measure inflammation?
Studies suggest that C-reactive protein is an important prognostic marker for cancer survival16-21. These findings appear to be independent of race, tumor stage, and body mass index3. There is some concensus among integrative cancer care providers for CRP levels below 1.0 mg/L.
In Anticancer, David Servan-Schreiber MD, PhD refers to researchers at the Glasgow Hospital in Scotland that recommend two predictive inflammatory blood markers in people with cancer—C-reactive protein and albumin. These markers appear to have been used reliably in other studies.
What is the history of anti-inflammatory agents?
Anti-inflammatory substances such as curcumin in turmeric have been used in some health care systems for several thousands of years. Research into the relationship between inflammation and disease began in the 1800s. German scientists observed a link between inflammation and cancer in the mid 1800s. An increasing amount of studies investigating the association between inflammation and cancer, as well as anti-inflammatory agents, have occurred over the last few decades.
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